C26H46N2O, or also known as cyclovirobuxine D, has for the first time been isolated from Buxus papilosa. It has a steroid nucleus in trans/cis/trans configuration. Two of the three cyclohexane rings adopt half-chair conformations and the third ring, with an equatorially attached methylamino substituent, is in a chair conformation. The cyclopentane ring has a half-chair conformation and the N-methylaminoethane group is equatorially attached to it. N-HO and C-HN interactions are observed in the molecular structure and the crystal structure is stabilized by van der Waals interactions
Cyclovirobuxine D is an active compound extracted from Buxus microphylla, which has been used for treating acute myocardial ischemia in China.It significantly reduced the infarct size induced by ligating the coronary artery in rats, and the effect was almost abolished by glibenclamide, a blocker of ATP sensitive potassium channel, but it was not influenced by cyclooxygenase-2 inhibitor celecoxib or estrogen receptor antagonist tamoxifen.
from:Natural standard substance
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