HCV genotyping is also no uniform standards for genotyping because of the location and the technology used in different ways , the emergence of a variety of genotyping results , but various genotypes classifications corresponding relationship between certain hereby give several genotype classification for reference ( table 26-2 ) .
Table 1 HCV genotype type variety of the correspondence between the
Table 26-2 HCV genotype type variety of the correspondence between the
The main source of infection of hepatitis C clinical type of acute subclinical and asymptomatic patients , chronic patients and virus carriers . Generally, patients before the onset of 12 days , the blood that is infectious , and infected more than 12 years . HCV main source of blood spread abroad 30-90 % of post-transfusion hepatitis is hepatitis C, of post-transfusion hepatitis in hepatitis C accounted for 1 /3. But can also through other means , such as vertical transmission , and sexually transmitted daily contact family and so on.
Enter containing HCV or HCV-RNA in plasma or blood products , usually after 6-7 weeks incubation period of acute onset , clinical manifestations general weakness, poor appetite , liver discomfort , 1/ 3 of patients with jaundice , ALT increased, anti-HCV antibodies. 50% of patients with clinical hepatitis C may develop chronic hepatitis.
Hepatitis C pathogenesis is still not clear when HCV replication in liver cells caused by changes in the structure and function of liver cells or interfere with protein synthesis in liver cells , can cause liver cell degeneration and necrosis , suggesting that HCV directly damage the liver, cause disease play a role. However, most scholars believe that cellular immunity may play an important role in pathological response was found as hepatitis C and hepatitis B , and its tissue infiltration mainly CD3 + cells , cytotoxic T cells (TC) specific target cells attack HCV infection , can cause liver cell damage.
Clinical observations have shown that people infected with HCV arising after protective immunity poor, again infection are different.
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