Information about CD14 ELISA Kit

CD14 (cluster of adverse 14), aswell accepted as CD14, is a animal gene.
The protein encoded by this gene is a basic of the congenital allowed system. CD14 exists in two forms, one anchored to the film by a glycosylphosphatidylinositol appendage (mCD14), the added a acrid anatomy (sCD14). Acrid CD14 either appears afterwards address of mCD14 (48 kDa) or is anon buried from intracellular vesicles (56 kDa).
The x-ray clear anatomy of animal CD14 (4GLP.pdb) reveals a monomeric, angled solenoid anatomy absolute a berserk amino-terminal pocket.
CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the apprehension of bacterial lipopolysaccharide (LPS). CD14 can bind LPS alone in the attendance of lipopolysaccharide-binding protein (LBP). Although LPS is advised its capital ligand, CD14 aswell recognizes added pathogen-associated atomic patterns.

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From:Elisa assay kits

Information about Cortisol ELISA Kit

Cortisol is a hormone secreted by the adrenal glands, play an important role in dealing with the pressure, so it is also known as "stress hormones". Cortisol can raise blood pressure, blood sugar level and immune inhibition. In pharmacology, synthetic cortisol, known as the hydrogen hydroxyl cortisol (hydrocortisone), in addition to adding cortisol deficiency, also as a treatment for allergies, and inflammation. First is promoted as a treatment for rheumatoid arthritis, cortisol is called the Compound E (synthetic E).

Blood cortisol levels will change in Japan, the highest level in the morning, dropped to the lowest at midnight. Newborn babies cortisol japan-china content change is not follow the above rules; Related laws of forming in two weeks to nine months old. Information about circadian rhythms, believe from the retina to the suprachiasmatic nucleus of hypothalamus (suprachiasmatic nuclei).

Studies have found that certain changes in cortisol levels and dysfunction of cortisol levels, depression, stress, also with low blood sugar, disease, fever, trauma, fear, pain, and extreme temperature will cause because of the pressure to the physiological reaction of related events.

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From:Elisa assay kits

The purpose of the Metal silicon

Into silicon used for smelting ferrosilicon alloy as alloying elements in steel industry, as a reducing agent in many kinds of metal smelting. Silicon or aluminum alloy good group in yuan, the vast majority of casting aluminium alloy containing silicon. Silicon is a raw material for electronic industry ultrapure silicon ultra pure monocrystalline silicon semiconductor electron device has small volume, light weight, good reliability and long service life, etc. Mixed with a certain number of trace impurities of high-power transistor, rectifier and solar cells, and is better than made of single crystal germanium. Amorphous silicon solar cell research progress quickly, conversion rate reached more than 8%. Silicon molybdenum rods highest use electric heating element temperature can reach 1700 ℃, has good resistance to aging and oxidation resistance. Chemical hydrogen silicon with silicon production, can make hundreds of silicone lubricants and waterproofing compound, etc. In addition, the silicon carbide can be abrasive, high purity silica quartz tube is made of high purity metal smelting and lighting lamps and lanterns is the important material. Paper in the eighty s - silicon people call for the "paper" in the eighty s. This is because the paper can only record information, and silicon can not only record information, also can carry on the processing of information processing in order to obtain new information. The world's first electronic computer made in 1945, with 18000 vacuum tubes, 70000 70000 resistor, capacitor, the whole machine weighed 30 tons, covers an area of 170 square meters, equivalent to 10 house size. Today the electronic computer, due to advances in technology and the improvement of the material, on a fingernail silicon wafers, can accommodate tens of thousands of transistors; And there are input, output, a series of functions such as computing, storage, and control information. Porous silicon calcium thermal insulation material microporous calcium silicon thermal insulation material is a kind of excellent thermal insulation material. It has small heat capacity, high mechanical strength, low thermal conductivity, noncombustible, non-toxic, tasteless, can be cut, transportation is convenient wait for a characteristic, can be widely used in metallurgy, electric power, chemical industry, ship, etc all kinds of thermal equipment and pipe. After the test, the energy saving efficiency is better than that of asbestos and cement, cement perlite and vermiculite insulation materials. Special silicon calcium materials can be used as a catalyst carrier, such as oil refining, automobile exhaust purification is widely used in many aspects.
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From:Organic Chemical Compound

What is Citicoline, CDP-Choline?

Citicoline, CDP Choline

Citicoline for cerebral metabolic activator, for nucleic acid derivatives, is the main coenzyme, phosphate ester synthesis eggs can promote brain cell respiration, improve brain function, strengthen the function of ascending reticular activating system structure, promote the awakening, reduce cerebral vascular resistance, improve cerebral blood circulation, lack and cerebral metabolism, important components of biological membrane is to build the human body. In the clinical mainly used in the treatment of traumatic brain injury and cerebrovascular accident caused by neurological sequelae.

Treatment of children with viral encephalitis, improves breathing, to lower blood pressure returned to normal. With citicoline promote the synthesis of lecithin, improve brain function, increase cerebral blood circulation, promote metabolism, brain and snooze and relevant improvement the action such as breathing. Methods: citicoline 200 mg in 10% glucose injection to 100 ml, static drop, 1 time/day, Ed) 3 ~ 20 days.

Citicoline is a cheaper PuYao, clinical for more than twenty years in China, has been recognized by the doctor. With innovative drug development trudging, many manufacturers to develop citicoline granules, enteric capsules and enteric-coated metformin hydrochloride, chewable and scattered pieces of new dosage forms, such as many products has entered clinical approval. Because of oral drugs can keep relatively stable blood drug concentration, become the choice of clinical application. Especially citicoline oral agents due to drug use is convenient, safe, and can be applied in neurology clinic, therefore is beneficial to the clinical promotion of the product.

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From:Natural herbal extracts

Meldrum 's acid easily ionized

Meldrum 's acid is the most easy to ionization of 1, 3 - dicarbonyl compounds. The pKa low of 4.97, as a common carboxylic acid. Mie acid an unusually high content of acid in the past 100 years has not get a perfect explanation completely, and therefore become a prominent problem in the theory of organic chemistry.

The first explanation is based on analysis of dipole. Arndt was proposed based on the interpretation of the stereo electronic effect. Arndt, points out that ordinary ester owing to two lone pair electrons in silane oxygen and conjugated carbonyl there are two possibilities: one is with carbonyl PI lowest empty orbital conjugate; One is with carbonyl sigma key antibonding orbital conjugate. Both can reduce the conjugated molecular energy, is a molecule in a more stable state, so the ordinary ester ground-state conformation is the advantage of Z type. As a result of the existence of ring, mie acid lactone structure forced half ester in the E type, thus preventing the lone pair electrons with carbonyl sigma key antibonding orbital conjugate effect, as a result of the carbonyl electrophilic sexual enhancement to a stable alpha carbon anion more effectively. Because it is two and a half ester work together in a methylene, the effect of equivalent to two times, so the mie acid is much higher than ordinary lactone acid.

This can explain better explain Meldrum 's acid high acidity, but the energy balance of later found this explanation explained only 50% of the reason, the remaining 50% can't explain. Someone in 2001 and 2004, respectively, in this acid using quantum chemistry do the different calculation, put forward from the perspective of more explanation. But so far there are still a lot of this problem space.

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From:Natural herbal extracts

What illnesses can be treated Hyodeoxycholic acid?

Hyodeoxycholic acid made from pig bile for a kind of ursodeoxycholic acid, inhibit the formation of bile acid and dissolved fat, lower cholesterol and triglycerides in the blood, suitable for Ⅰ type a or b Ⅰ hyperlipidemia, sclerosis of arterial congee appearance, but also to bordetella pertussis, diphtheria bacillus and staphylococcus aureus has certain bacteriostasis, also can be used as an anti-inflammatory drugs, the treatment of chronic bronchitis, infantile viral upper respiratory tract inflammation, etc.

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From:Raw pharmaceutical materials

What is Electronic grade titanium dioxide?

High purity Electronic grade titanium dioxide has the performance of the semiconductor, its electrical conductivity with temperature rising and increased rapidly, but also very sensitive to hypoxia. Dielectric constant and the semiconductor properties of rutile type titanium dioxide is very important for the electronics industry, high purity titanium dioxide (electronic) can be used in the production of ceramic capacitors and other electronic components.

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From:metal materials

The Discovery of Coenzyme Q10 and history

CoQ10（Coenzyme Q10）was aboriginal apparent by Professor Fredrick L. Crane and colleagues at the University of Wisconsin–Madison Enzyme Institute in 1957.In 1958, its actinic anatomy was appear by Dr. Karl Folkers and coworkers at Merck. In 1961 Peter Mitchell proposed the electron carriage alternation (which includes the basic protonmotive role of CoQ10) and he accustomed a Nobel cost for the aforementioned in 1978. In 1972, Gian Paolo Littarru and Karl Folkers alone approved a absence of CoQ10 in animal affection disease. The 1980s witnessed a abrupt acceleration in the amount of analytic trials due to the availability of ample quantities of authentic CoQ10 and methods to admeasurement claret and claret CoQ10 concentrations. The redox functions of CoQ in cellular activity assembly and antioxidant aegis are based on the adeptness to barter two electrons in a redox aeon amid ubiquinol (reduced CoQ) and breakable CoQ (ubiquinone).The antioxidant role of the atom as a chargeless abolitionist scavenger was broadly advised by Lars Ernster. Numerous scientists about the apple started studies on this atom back again in affiliation to assorted diseases including cardiovascular diseases and cancer.

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From:Natural herbal extracts

Introduction of Fenugreek seed extract

Fenugreek seed extract for leguminous plants Dijon fenugreek Trigonella foenum graecum - l. seed, with the kidney, dispelling cold, analgesic effect and so on, used for kidney empty cold, stomach cold symptoms such as pain, small intestine colic, cold dampness beriberi.

Plant characteristics: annual herb, 20-80 cm, with full aroma. Stem erect, much forested, be thin hair. Three ternate alternate; Lobular long ovate or lanceolate, oval 1-3.5 cm long, 0.5 1.5 cm wide, both sides are rusty villous; Petiole, leaf and petiole commissure. Flower without terrier, 1 ~ 2 altar flowers; Calyx tubular; Gradient after corolla butterfly, white, light yellow, base microstrip purple; Stamens 10, two body; Ovary linear, pods, slender and oval tubular, slightly curved, 6 to 11 cm long, 0.5 cm wide, with a network of arteries and veins and pilose, apex with long beak. 10 ~ 20 grains, seeds brown, has a fragrance. Flowering from April to June, fruiting 7 ~ 8 month.

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