Introduction of Lacidipine

Lacidipine is a calcium channel blocker. It is available as tablets containing 2 or 4 mg.
lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity, resulting in a lack of reflex tachycardia. It has a long duration of action and a high degree of vascular selectivity. In addition to calcium channel-modulated vasodilation, lacidipine displays antioxidant activity greater than that of other dihydropyridine calcium antagonists. In randomised, well-controlled trials, lacidipine 2-6 mg orally once daily had antihypertensive efficacy similar to that of other long-acting dihydropyridine calcium antagonists, thiazide diuretics, atenolol (a beta-blocker) and enalapril (an ACE inhibitor). Lacidipine was effective in elderly patients (including those with isolated systolic hypertension), African Nigerian patients and patients with concurrent type 2 diabetes mellitus.
Lacidipine is an effective, well tolerated, once-daily, oral antihypertensive agent that can be used in a wide variety of patients. As with other members of its class, lacidipine has shown potentially beneficial antiatherosclerotic effects, although definitive data with respect to possible superiority over other drug classes are still required. Therefore, lacidipine is an attractive therapy for the long-term management of essential hypertension.
from:Natural standard substance

Properties of

Name:Low-Silica Chrome Concentrate
Specification:
Cr2O3: 56% basis 54%min
Cr:Fe Ratio: 2.8:1min
MgO: 14%max
SiO2: 1.5%max
Al2O3: 14%max
S: 0.03%max
P: 0.007%max
Size: 0-3mm 90%min
from:Rare Metals

what is the Cefoperazoneis?

Cefoperazoneis one of few cephalosporin antibiotics effective in treating Pseudomonas bacterial infections which are otherwise resistant to these antibiotics.
Cefoperazone is a combination of sulbactam and cefoperazone. Cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall  synthesis, and sulbactam acts as a beta-lactamase inhibitor, to increase the antibacterial activity of cefoperazone against beta-lactamase producing organisms. In some countries, the combination is sold as Sulperazone. Gepach International markets this combination of Cefoperazone with Sulbactam under the brand name Bacperazone.
CAS:62893-19-0
Molecular Formula:C25H27N9O8S2
Formula Weight:645.67
from:Acridine Raw Material

what is the Aluminium tristearate?

Aluminium tristearate is a soft, fine fluffy free flowing bulky powder having characteristic odor. It has mild antiseptic and astringent properties.
It imparts smoothness to creams. It is a normal Aluminium soap of Stearic Acid and finds users in many industries. It is water repellent by nature and insoluble in water.
CAS:637-12-7
Molecular Formula:C54H105AlO6
Formula Weight:877.39
from:Acridine Raw Material

about Naringin

Naringin is a flavanone-7-O-glycoside between the flavanone Naringenin and the disaccharide neohesperidose. The flavonoids naringenin and hesperetin, which form the aglycones of naringin and hesperidin, occur naturally in citrus fruits, especially in grapefruit, where naringin is responsible for the fruit's bitter taste. In commercial grapefruit juice production, the enzyme naringinase can be used to remove the bitterness created by naringin. In humans the naringin is metabolized to the flavanone naringenin.
The chemical formula of the compound is C27H32O14. It has a molecular weight of 580.53 and in its purest form, the compound appears as a yellow powder. Chemically, it is a conjugate of a sugar molecule and naringenin, which is another flavonoid present in grapefruit.
Generally, flavonoids protect cells from molecules that contain reactive oxygen atoms, commonly called free radicals. Usually, flavonoids reduce the damaging effects of free radicals by stimulating the production of glutathione, which is a strong anti-oxidant. Flavonoids can also increase the effectiveness of vitamin C as an anti-oxidant. In addition, flavonoids play a role in inflammation control by moderating certain cells of the immune system. They can also inhibit the activity of certain types of viruses, including the herpes simplex virus.
from:Natural standard substance

Introduction of Geniposide

Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has been shown to regulate Nrf2 translocation and upregulate downstream antioxidant protein HO-1 expression through the PI3K/Akt signaling pathway, which may account for its neuroprotective and antioxidative activity. Glucagon-like peptide 1 (GLP-1) receptor may also play a critical role in geniposide induced HO-1 expression.
CAS : 24512-63-8
Molecular Formula : C17H24O10
Formula Weight : 388.37
Description :
Geniposide   has been reported to have a hypoglycemic effect.
Source: the fruit of Gardenia jasminoides
Appearance:little yellow crystal.
from:Acridine Raw Material

Cyclovirobuxine D is an anti-atrial fibrillating agent

C26H46N2O, or also known as cyclovirobuxine D, has for the first time been isolated from Buxus papilosa. It has a steroid nucleus in trans/cis/trans configuration. Two of the three cyclohexane rings adopt half-chair conformations and the third ring, with an equatorially attached methylamino substituent, is in a chair conformation. The cyclopentane ring has a half-chair conformation and the N-methylaminoethane group is equatorially attached to it. N-HO and C-HN interactions are observed in the molecular structure and the crystal structure is stabilized by van der Waals interactions
Cyclovirobuxine D is an active compound extracted from Buxus microphylla, which has been used for treating acute myocardial ischemia in China.It significantly reduced the infarct size induced by ligating the coronary artery in rats, and the effect was almost abolished by glibenclamide, a blocker of ATP sensitive potassium channel, but it was not influenced by cyclooxygenase-2 inhibitor celecoxib or estrogen receptor antagonist tamoxifen.
from:Natural standard substance