CD14 (cluster of adverse 14), aswell accepted as CD14, is a animal gene.
The protein encoded by this gene is a basic of the congenital allowed system. CD14 exists in two forms, one anchored to the film by a glycosylphosphatidylinositol appendage (mCD14), the added a acrid anatomy (sCD14). Acrid CD14 either appears afterwards address of mCD14 (48 kDa) or is anon buried from intracellular vesicles (56 kDa).
The x-ray clear anatomy of animal CD14 (4GLP.pdb) reveals a monomeric, angled solenoid anatomy absolute a berserk amino-terminal pocket.
CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the apprehension of bacterial lipopolysaccharide (LPS). CD14 can bind LPS alone in the attendance of lipopolysaccharide-binding protein (LBP). Although LPS is advised its capital ligand, CD14 aswell recognizes added pathogen-associated atomic patterns.
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